Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides.
نویسندگان
چکیده
Synthesis of chimeric 9-mer oligonucleotides containing methylphosphonate-linkages and locked nucleic acid (LNA) monomers, their binding affinity towards complementary DNA and RNA, and their 3'-exonucleolytic stability are described. The obtained methylphosphonate-DNA/LNA chimeric oligonucleotides display similarly high RNA affinity and RNA selectivity as a corresponding 9-mer DNA/LNA chimeric oligonucleotide, but much higher resistance towards 3'-exonucleolytic degradation.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 19 10 شماره
صفحات -
تاریخ انتشار 2009